Physiologic Manifestations of Human Anapf is

tion of the cardiopulmonary changes observed during anaphylactic shock. The two subjects with the most severe shock showed evidence of intravascular coagulation characterized by a diminution of Factor V, Factor VIII, fibrinogen, and high molecular weight kininogen, as well as changes in components of the complement system. Standard therapy with epinephrine and fluids, usually recommended for the treatment of systemic anaphylaxis, did not immediately reverse either the hemodynamic or the respiratory abnormalities in the two subjects with the most severe This paper is publication No. 408, O'Neill Laboratories, Good Samaritan Hospital, Baltimore, Md. 21239. Dr. Kaplan's present address is State University of New York at Stony Brook, Health Sciences Center, Stony Brook, N. Y. Received for publication 18 March 1980 and in revised form 30 June 1980. 1072 J. Clin. Invest. C The American Society for anaphylactic shock. Hemodynamic recovery was gradual and did not seem directly related to any specific therapeutic intervention.